Dear investor, colleague and friend,

At Venture Science, we are driven by a passion for identifying and supporting visionary companies. Our investments are rooted in a commitment to transforming industry through groundbreaking technologies — and in the belief, held since our founding, that a calculated, quantitative approach beats heuristics over any meaningful time horizon.

That belief is now encoded into everything we do. Helix, our AI operating platform, connects every layer of the firm through a single intelligence layer — from deal sourcing and portfolio analysis to fund operations and LP communications. It's built on a proprietary knowledge base assembled over more than a decade: academic research, internal investment memos, portfolio outcome data, and scoring models calibrated against real results. Helix isn't a tool we adopted. It's the platform we built because our approach demanded it.

With this foundation, we seek out high-potential companies tackling some of the most complex challenges in the world. From space technology to precision medicine to advanced diagnostics, our portfolio reflects our belief in the power of innovation to create meaningful impact and substantial returns.

Our network spans academic institutions, industry leaders, and entrepreneurial talent — allowing us to not only identify transformative opportunities but also provide strategic guidance and resources to help our portfolio companies thrive. We are proud to partner with bold entrepreneurs who share our vision of a future where cutting-edge technology transforms lives.

Located in the San Francisco Bay Area, we benefit from unparalleled access to one of the most dynamic innovation ecosystems in the world. Being immersed in this environment allows us to identify and invest in some of the most promising companies — and Helix ensures we evaluate every one of them with discipline and depth.

Whether you're an entrepreneur driving the next breakthrough or an investor looking to be part of this journey, we'd love to hear from you.

Sincerely,

Matt